Endocrine Abstracts

Introduction: Increased hepatic de novo lipogenesis (DNL) is often associated with greater intrahepatic triglyceride (IHTG) content and/or decreased insulin sensitivity; however, the contribution of DNL to each has not been fully elucidated. Therefore, the present work determined if increased DNL, achieved via adoption of an isocaloric high-sugar diet, resulted in concomitant increases in IHTG content and/or decreases in insulin sensitivity.Methods: Sixt...

SEMDs are a heterogeneous group of skeletal disorders characterised by defective growth and modelling of the spine and long bones. Genetic defects in two inherited SEMDs have been identified and these involve abnormalities of the collagen type II gene located on chromosome 12q12-q13.2, and an ATP sulfurylase/APS kinase gene located on 10q23-34. These are not the cause of the Missouri variant (SEMDMO), which occurs as an autosomal dominant trait in a unique four-gene...

Background: Intrahepatic triglyceride (IHTG) accumulation, a cardiometabolic disease risk factor, is greater in individuals consuming saturated-fat (SFA) compared to polyunsaturated-fat (PUFA) enriched diets. We have demonstrated that compared to SFA, PUFA are preferentially partitioned into oxidation pathways, which may, in part, explain the divergence in IHTG accumulation. However, it remains unclear if this preferential handling is maintained when hepatocel...